Fig. 5: Co-occurrence network architecture and topological properties at 96 weeks of ART. | Nature Communications

Fig. 5: Co-occurrence network architecture and topological properties at 96 weeks of ART.

From: Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial

Fig. 5: Co-occurrence network architecture and topological properties at 96 weeks of ART.

A Side-by-side SPRING-derived genus-level networks for patients treated with dolutegravir (left) versus darunavir/ritonavir (right) at week 96. Nodes represent genera (colored by phylum), and node size is proportional to CLR-transformed relative abundance. Only the 200 most prevalent genera (prevalence ≥15%) are shown, with edges weighted by signed association strength. Layouts are held constant between panels for direct visual comparison; isolated singletons present in both networks have been removed. B Heatmap of the differential Graphlet Correlation Matrix (ΔGCM = GCM_dolutegravir – GCM_darunavir/ritonavir) computed on the largest connected component at week 96. Each cell displays the change in Spearman correlation between a pair of non-redundant graphlet orbit counts; red shades indicate orbit pairs more positively correlated in dolutegravir; blue shades indicate stronger correlations in darunavir/ritonavir. Numerical labels give Δρ, and asterisks denote FDR-adjusted significance of the difference (*q value < 0.05; **q value < 0.01; ***q value < 0.001). Bounding boxes group orbits by their topological role (degree, chain, cycle, terminal). See Supplementary Table 4 for a detailed description of the graphlet orbits. Source data are provided as a Source data file.

Back to article page