Fig. 3: Chromatin distance affects orientation-specific CSR. | Nature Communications

Fig. 3: Chromatin distance affects orientation-specific CSR.

From: Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination

Fig. 3: Chromatin distance affects orientation-specific CSR.The alternative text for this image may have been generated using AI.

a A Schematic of the Igh locus from V(D)J exon to 3′CBEs in IαΔ cells and an illustration of the generation of γ3Inv, γ3Inv-γ3Inv, and γ3IRD cells. Joining features of Sμ−Sγ3 junctions in IαΔ (b), γ3Inv (c), γ3Inv-γ3Inv (e), and γ3IRD (f) cells. d Bar graph shows the inversional joining of Sμ−Sγ3 junctions in IαΔ, γ3Inv, γ3Inv-γ3Inv, and γ3IRD cells. Data are presented as mean ± s.e.m. from three independent experiments. P-values were calculated via an unpaired two-tailed Student’s t-test. Source data are provided as a Source Data file.

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