Fig. 4: Inverted promoter of CHs promotes inversional CSR.
From: Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination
a CSR-HTGTS-seq, Pro-seq, 3C-HTGTS with iEμ/Iμ (blue asterisks), and Rad21 ChIP-seq to show the CSR junctions, transcription status, chromatin interaction, and cohesin binding of the Igh locus from Iγ3-FS-Cα cells. b CSR-HTGTS-seq, Pro-seq, 3C-HTGTS with iEμ/Iμ bait (blue asterisks), and Rad21 ChIP-seq to show the CSR junctions, transcription status, chromatin interaction, and cohesin binding of the Igh locus from Iγ3-FS-Iα cells. c CSR-HTGTS-seq, Pro-seq, 3C-HTGTS with iEμ/Iμ (blue asterisks), and Rad21 ChIP-seq to show the CSR junctions, transcription status, chromatin interaction, and cohesin binding of the Igh locus from Iγ3-PS-Cα cells. d CSR-HTGTS-seq, Pro-seq, 3C-HTGTS with iEμ/Iμ bait (blue asterisks), and Rad21 ChIP-seq to show the CSR junctions, transcription status, chromatin interaction, and cohesin binding of the Igh locus from Iγ3-PS-Iα cells. For (a–d), data are presented as mean ± s.e.m. from three independent experiments. Source data are provided as a Source Data file.
