Fig. 8: FA-P@MC ameliorated plaque and inflammation in atherosclerotic mice. | Nature Communications

Fig. 8: FA-P@MC ameliorated plaque and inflammation in atherosclerotic mice.

From: A hierarchical theranostic nanoagent for multimodal imaging and targeted foam cell intervention in atherosclerosis

Fig. 8: FA-P@MC ameliorated plaque and inflammation in atherosclerotic mice.The alternative text for this image may have been generated using AI.

a Schematic of the experimental procedure for AS modeling, treatment administration, and outcome evaluation in ApoE−/− mice. Created in BioRender. Li, W. (2026) https://BioRender.com/w6tdj6p. b Representative images of ORO-stained aortas and c corresponding quantitative analyses following different treatments (n = 6 mice). Scale bars: 5 mm. d Representative H&E-stained images and e corresponding quantitative analyses of plaque area across different treatment groups (n = 6 mice). Scale bar: 500 μm. f Representative DHE-stained images and g corresponding quantitative analyses of plaque DHE fluorescence across different treatment groups (n = 6 mice). Scale bar: 500 μm. h Western blot analysis of CD47 protein expression in aortas from mice treated with various formulations. i Immunofluorescence staining images showing the CD47 expression and CD68-positive macrophages in aortic sinus sections across different groups. Scale bar: 25 μm. j Quantitative analyses showing the MFI of CD47 under different treatment conditions (n = 6 mice). All data are expressed as mean ± SD. For h experiment was repeated three times independently with similar results. For c, e, g, j statistical significance was determined using one-way ANOVA for multiple comparisons. Source data are provided as a Source Data file.

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