Fig. 5: Regional specificity of CREs in cortical non-neuronal cells.
From: Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex
a Heatmap showing the percentages of OPCs and OLGs among all glial cells in various brain regions of the macaque cortex after spatial mapping. The brain regions are ordered by the decreasing percentage of OPCs. b Correlation between the percentage of OPCs and OLGs in various cortical regions in the visual system. Brain regions are colored by their hierarchical levels. Correlation coefficients and P values were calculated by Spearman correlation analysis. c Genome browser track view showing one mammal-conserved CRE linked to the TSS region of PDGFRA in OPCs. d Genome browser track view showing one human/macaque-biased CRE linked to the TSS region of FBLN2 in OPCs. e Heatmap showing the chromatin accessibility of CREs in protoplasmic and interlaminar astrocytes. f Dot plot showing the hub score of enriched TFs in the GRNs of interlaminar and protoplasmic astrocytes. The x-axis is ordered by the decreasing hub scores of TFs in the GRNs. g Gene regulatory network of TFs and targeted genes in interlaminar astrocytes. h Genome browser tracks showing the chromatin accessibility of CRE linked to MMP28 between protoplasmic and interlaminar astrocytes. i Spatial maps of expression patterns of ID3 and MMP28, and chromatin accessibility of the CRE linked to MMP28 at a representative section (EBZ + 10). j Bar plots showing quantitative levels of ID3 and MMP28 expression as well as chromatin accessibility of the CRE linked to MMP28 across six cortical layers. The sample sizes are listed in Supplementary Data 10. Error bars represent SEM.
