Fig. 4: Condensin regulates the interphase budding yeast genome. | Nature Communications

Fig. 4: Condensin regulates the interphase budding yeast genome.

From: Condensin accelerates long-range intra-chromosomal interactions

Fig. 4: Condensin regulates the interphase budding yeast genome.The alternative text for this image may have been generated using AI.

A Hi-C contact matrices over chrIV and chrXV in G1-arrested WT and Smc4-AID strain ±IAA. The log2 fold change between Smc4-AID +IAA and WT is shown on the right. B Pair-wise contact frequencies as a function of genomic distances in WT or Smc4-depleted conditions. Region pairs within the right arms of chrIV and ChrXV, or across between the left and right arms, are used for this calculation. The lower panels show the Smc4 ±IAA / WT and Smc4+IAA/−IAA ratio. C ChIP-exo data of Smc4 and Brn1 (another condensin subunit) on ChrIV and ChrXV. D Inter-chromosomal contact frequencies between ChrIV and ChrXV in G1-arrested WT strain and Smc4-AID strain ±IAA. N = 10051, 9523, and 9732 contacts for WT, Smc4 −IAA, and Smc4 +IAA. Box plot notation: center line, median; box limits, 25th and 75th percentiles; boundaries of the whiskers, minimum and maximum values; points, outliers. Statistical analysis is based on two-tailed students’ t test.

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