Fig. 4: BGC gene variations can only partially explain secondary metabolite differentiation. | Nature Communications

Fig. 4: BGC gene variations can only partially explain secondary metabolite differentiation.

From: Large-scale multi-omics profiling reveals environmental and evolutionary drivers of fungal phylogeographic and metabolic diversity

Fig. 4: BGC gene variations can only partially explain secondary metabolite differentiation.The alternative text for this image may have been generated using AI.

a Experimentally characterized BGC core gene presence/absence variation (PAV) only partially explains specialized metabolites’ abundance profiles. For example, in aflatoxin BGC, 34% of W-clade 1 and 14% of W-clade 6 strains showed multiple peripheral gene loss events, 44% strains without core gene loss events still showed no/low aflatoxin production. b The differentially expressed gene ranking dotplot of 58 BGCs of 28 strains in Chinese clade4/clade1. c Results of pathway enrichment analysis of differentially expressed genes in C-clade4/clade1. d Results of pathway enrichment analysis of differentially expressed genes in C-clade4/clade3. e Results of pathway enrichment analysis of differentially expressed genes in C-clade3/clade1. f Results of pathway enrichment analysis of differentially expressed genes in C-clade6/clade3. g Results of pathway enrichment analysis of differentially expressed genes in C-clade6/clade4.

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