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SNXs take center stage in endosomal sorting

Nature Cell Biology volume 21, pages 1175–1177 (2019)Cite this article

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Endosomes are central stations for converging proteins from biosynthetic pathways and endocytic routes. Many endosomal proteins are sorted to the plasma membrane or the Golgi despite the lysosome being the primary endosomal fate. SNX5 and SNX6 are now revealed to decode a conserved bipartite signal to mediate protein sorting to the Golgi or the plasma membrane.

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Fig. 1: Schematic highlighting the sorting roles of the endosomal network.

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Authors and Affiliations

  1. Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore

    Wanjin Hong

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  1. Wanjin Hong
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Correspondence to Wanjin Hong.

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Hong, W. SNXs take center stage in endosomal sorting. Nat Cell Biol 21, 1175–1177 (2019). https://doi.org/10.1038/s41556-019-0401-7

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