Extended Data Fig. 9: Single-cell RNA sequencing of the atherosclerotic lesion to identify anti-atherosclerotic mechanisms of nt-LNA treatment.
From: LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8
a) Apoe-/- mice fed an atherogenic diet for 4 weeks were injected once weekly with saline control (Ctr; n = 8) or nt-LNA (30 mg/kg; n = 8). b) UMAP projection of unbiased clusters obtained from atherosclerotic lesions. c) Relative contribution of cells from saline (Ctr) and nt-LNA treated mice to each cluster of (b). d) Relative expression (color) and % of cells reaching threshold of detection (size) of transcripts pertaining to T cell and NK cell phenotypes (top) or B-cell phenotypes (bottom) in atherosclerosis for each cluster. Numerical source data, statistics, exact p values and q values are provided.
