Extended Data Fig. 4: Renal and brain dysfunction in response to liver senescence.
From: Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
(a) Urine levels of Glutamine, Serine and Valine identified by liquid chromatography-mass spectrometry (LC-MS) in ΔMdm2Hep mice pre- and post- AAV-Cre injection: dots represent the average peak area of n=3 mice at days -2 and 0, n=4 mice at day 4 and n=5 mice at days -1 and 3; 2-way ANOVA comparing each time point to induction day (day 0). (b) Proportion of time spent by control and ΔMdm2Hep mice in the novel arm of the Y-maze 4 days before and 4 days after AAV injection: dots represent the average percentage of time spent in the novel arm for n=7 and 9 for control and ΔMdm2Hep mice respectively; 2-way ANOVA. Area under the curve (area power) (c) and frequency (Hz) (d) of the brain slice oscillations after stimulation with carbachol. n=14 brain slices (except n=12 at times 0,15,60 and 105) from 4 control mice and n=14 brain slices from 4 ΔMdm2Hep mice for every time point. Throughout all bars are mean ± S.E.M. and the numbers on the graphs are p values. Source numerical data are available in source data.
