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Harnessing lysohormesis for healthy ageing

Nature Cell Biology volume 27, pages 548–551 (2025)Cite this article

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Lysosomal dysfunction is emerging as a common pathogenic mechanism underlying normal ageing and many age-related diseases. Lysohormesis, the triggering of beneficial adaptations by mild lysosomal stress leading to increased lysosomal function and cellular stress resilience, could provide a common solution to many age-related issues.

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Fig. 1: Cellular hormesis increases stress resilience through lysosomes.
Fig. 2: The concept and mechanisms of lysohormesis.
Fig. 3: Therapeutic potential of induced and endogenous lysohormesis.

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Acknowledgements

The author thanks Aging Institute members at the University of Pittsburgh for feedback. The laboratory of J.X.T. is supported by start-up funding from the Aging Institute at the University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center (UPMC) and from the National Institute of General Medical Sciences of the US National Institutes of Health (NIH) under the award number R35GM150506.

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  1. Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Jay Xiaojun Tan

  2. Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jay Xiaojun Tan

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  1. Jay Xiaojun Tan
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Correspondence to Jay Xiaojun Tan.

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Tan, J.X. Harnessing lysohormesis for healthy ageing. Nat Cell Biol 27, 548–551 (2025). https://doi.org/10.1038/s41556-025-01634-9

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