Lysosomes articles from across Nature Portfolio

The ubiquitin ligase RNF183 regulates the ion transporter NKCC1 under hyperosmotic stress through ubiquitin-dependent mechanisms, providing new insights into osmoadaptive regulation of membrane transporters.

Lysosome positioning is essential for cell metabolism and stress responses. Here, the authors show that the TMEM55B-associated protein TBC1D9B controls lysosome positioning, autophagy, and starvation-induced degradation by serving as a GTPase activating protein of ARL8B

Using human neuronal and microglia cells, Chakraborty et al. find that the incapability of neuronal cells to efficiently degrade α-Synuclein aggregates results in transfer to microglia in a contact-dependent manner, thereby outsourcing aggregate clearance.

The authors demonstrate the multifaceted role of LYSET in stabilizing GNPT at the Golgi, by resolving the topology of LYSET and identifying several critical regions for LYSET function and stability.

Cells lining the kidney proximal tubule are densely packed with lysosomes, but little is known about their dynamic activity in situ. Here, the authors use intravital imaging and targeted probes to study lysosomal behavior along the kidney proximal tubule, and discover substantial axial heterogeneity in lysosomal dynamics, organellar interactions and metabolic functions.

A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM175-mediated proton efflux, organelle positioning and neurodegeneration.

mTORC1 promotes cell growth by sensing nutrients and driving anabolic processes. When nutrients are scarce, GATOR1 turns off growth signals. Our study describes how KICSTOR links GATOR1 to lysosomes to enable its function, a finding that may help us to understand certain neurological disorders.

Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.