Extended Data Fig. 1: ALDH4A1 protein levels are downregulated in various human cancers and its loss predicts poor survival outcome. | Nature Cell Biology

Extended Data Fig. 1: ALDH4A1 protein levels are downregulated in various human cancers and its loss predicts poor survival outcome.

From: ALDH4A1 functions as an active component of the MPC complex maintaining mitochondrial pyruvate import for TCA cycle entry and tumour suppression

Extended Data Fig. 1: ALDH4A1 protein levels are downregulated in various human cancers and its loss predicts poor survival outcome.

(a, b) The gene expression of ALDH4A1 patterns across diverse human cancer and normal tissues from GENT (gene expression database of normal and tumor tissues). Significant test results P < 0.001 by two-sample t-test were indicated on web-accessible database of GENT (http://gent2.appex.kr/gent2/). The centre lines in the boxes represent median values. The box edges, upper and lower whiskers indicate the interquartile range (IQR; from the 1 to 3.7), the largest value smaller than 3.7 and the smallest value larger than 1 (a) and Oncomine publicly accessible database (b) P < 0.001 by Mann-Whitney U test. (c) The overall survival rate of patients with high or low ALDH4A1 expression from PrognoScan. P < 0.05 by long-rank test. (d) The database extracted from Kaplan-Meier Plotter was subjected to Kaplan-Meier analysis. (e) The percentage of cases from TCGA database (https://portal.gdc.cancer.gov) indicates loss of copy number variation (CNV) of ALDH4A1 in several cancer types including adenomas and adenocarcinomas from brain, liver, lung, stomach, pancreas, bladder, kidney, etc.

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