Extended Data Fig. 2: Profiles of enhancers associated with risk SNP.
From: Systematic decoding of functional enhancer connectomes and risk variants in human glioma
a. CRISPR interference with risk SNP-associated enhancers significantly inhibits glioma cell proliferation. Data represent means ± SD from three independent biological replicates. Statistical significance was determined by two-sided t-test, ** P < 0.01, *** P < 0.001, N.S, not significant. b, c. H3K27ac HiChIP interaction maps at 5 Kb resolution, centered on the rs2297440 (b) and rs3851634 (c) loci, respectively, in glioma tissue, glioma cells, and normal brain.
