Extended Data Fig. 2: Nox1 and Npy1r are not enriched in small intestine stem cell clusters.
From: NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo
a) Heatmap representing the level of expression of identified key lineage markers for each cluster in the proximal, middle, and distal small intestine; b) UMAP plots representing all the clusters identified (left panel) before being reassigned in different lineage clusters using the expression heatmap in a) (right panel); c) UMAP plots representing the distribution of Lgr5+ (upper panel), Nox1+ (middle panel), and Npy1r+ cells (lower panel) for each intestinal region (proximal, middle, and distal small intestine). Stem cell (SC) cluster is delineated in blue dashed line and enteroendocrine (EE) cluster is delineated in brown dashed line according to the lineage clusters defined in b). Assay was performed on one biological sample per tissue region.
