Fig. 5: CoCo-ST analysis and spatial niche identification in Visium HD datasets. | Nature Cell Biology

Fig. 5: CoCo-ST analysis and spatial niche identification in Visium HD datasets.

From: CoCo-ST detects global and local biological structures in spatial transcriptomics datasets

Fig. 5: CoCo-ST analysis and spatial niche identification in Visium HD datasets.The alternative text for this image may have been generated using AI.

a, The Visium HD tissue samples designated as the background and foreground datasets for CoCo-ST analysis. b, UMAP embedding of the CoCo-ST reference data from VHD1. c, Full embedding of the overall VHD1 samples onto the reference determined by CoCo-ST. d, UMAP embedding of the CoCo-ST reference data from VHD2. e, Full embedding of the overall VHD2 samples onto the reference determined by CoCo-ST. f, Spatial spot clusters detected by CoCo-ST on the VHD1 and VHD2 datasets. g, Spatial niches detected by CoCo-ST on the VHD1 and VHD2 datasets. Genome-wide analysis (b–g) was performed on two independent biological samples (VHD1 and VHD2).

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