Fig. 5: Loss of TAD-like domains at escapee clusters occurs owing to gene silencing by Xist RNA. | Nature Cell Biology

Fig. 5: Loss of TAD-like domains at escapee clusters occurs owing to gene silencing by Xist RNA.

From: Escape from X inactivation is directly modulated by Xist noncoding RNA

Fig. 5: Loss of TAD-like domains at escapee clusters occurs owing to gene silencing by Xist RNA.

a–c, Capture Hi-C interactions and insulation score at the Mecp2–Hcfc1 cluster for the Xi in clone CL30.7 are shown. Capture Hi-C interactions are shown for the Xa and the Xi in the untreated condition (a), upon Dox treatment for 21 days (b) and after 23 days of auxin treatment and 21 days of Dox treatment (c). Capture Hi-C data are shown at 10 kb resolution. Heat maps show allelic ratios for 29 X-linked genes included in the captured region. Differential maps show changes in genome topology between 21-day Dox-treated samples and control samples (b) and 23-day auxin and 21-day Dox-treated samples compared with control samples (c).

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