A newly discovered acidic nanolayer that envelopes lysosomes reveals that proton gradients extend beyond the organelle lumen, identifying a nanoscale regulatory interface that links luminal pH, TMEM175-mediated proton efflux, organelle positioning and neurodegeneration.
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Stagi, M. Decoding the proton veil around lysosomes. Nat Cell Biol (2026). https://doi.org/10.1038/s41556-025-01869-6
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DOI: https://doi.org/10.1038/s41556-025-01869-6
