Extended Data Fig. 6: Sphingolipid profiling of lysates and large vesicle fraction containing ectosomes in dopaminergic neurons.
From: Glucosylceramide-induced ectosomes propagate pathogenic α-synuclein in Parkinson’s disease
a, Schematic overview of sphingolipid pathway, species are color coded, GCase and important lipids in bold. b-q, Abundance of lipids in lysates and large extracellular vesicle fractions (lEV) from GBA1-N370S neurons and isogenic corrected controls. n = 5 independent experiments from separate inductions; Mean ± SEM; Two-tailed unpaired t-tests with Šidák’s correction for multiple comparisons. Graphs are depicted as superplots where biological replicates are shown in large shapes, and technical replicates are shown as small shapes.
