Extended Data Fig. 1: Distribution of individual mutational fitness effects and inferred Ω and 1-α under various conditions.
From: Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution
a, Fitness effects of individual beneficial non-synonymous mutations in the 21 yeast genes. Each dot represents the point estimate of the fitness effect of a mutation, with its standard error shown by the error bar. Red indicates a significant fitness effect (nominal P < 0.05), whereas grey indicates a non-significant fitness effect. b–c, Inferred Ω (b) and 1-α (c) when various statistical stringencies are applied in calling significant fitness effects of mutations. Under a statistical cutoff, Ω and 1-α are estimated by setting all non-significant fitness effects at 0. d–e, Inferred Ω (d) and 1-α (e) when asexual populations are considered. f–g, Inferred Ω (f) and 1-α (g) when the effective population size (Ne) is 104. See Fig. 1b,c for symbol definitions.
