Extended Data Fig. 8: Cell type gene regulatory networks. | Nature Ecology & Evolution

Extended Data Fig. 8: Cell type gene regulatory networks.

From: Decoding cnidarian cell type gene regulation

Extended Data Fig. 8: Cell type gene regulatory networks.The alt text for this image may have been generated using AI.

a, Number of TFs in GRNs inferred for each broad cell type (top), number of genes targeted by each TF (middle), and fraction of overlapping target genes for each pair of TFs (bottom). b, Overlap of target genes for the same TF across cell types, plotted for groups of TFs active in different number of cell types. Selected TFs are highlighted on the plot and overlap of their target genes is shown as Euler diagrams below. c, Number of CREs per target gene (x-axis) compared to number of CREs of the same gene with any single TF motif (y-axis). Most TFs have binding motif in a single CREs of their target genes. d-g, Additional inferred GRN and TF connectivity measurements for neuro-secretory cell types: GATA/Islet neurons (d-e), Pou4/FoxL2 neurons (f-g) and gland cells (h-i). Asterisks highlight TFs known to be involved in neurosecretory development.

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