Extended Data Fig. 3: Examples of ancient conserved microsyntenic blocks located within TAD boundaries. | Nature Ecology & Evolution

Extended Data Fig. 3: Examples of ancient conserved microsyntenic blocks located within TAD boundaries.

From: Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes

Extended Data Fig. 3

Sea star (left panels) and sea urchin (right panels) genomic regions around four developmental genes included within ancient microsyntenic blocks (Tbx2/3, Foxa and Pax1/9, and Egr). From top to bottom: heatmaps showing normalized HiC signal at 10-kb resolution in late gastrula sea star and sea urchin embryos, ATAC-seq signal at late gastrula stage embryos of both species, IDR ATAC-seq peaks (pCREs), conserved ATAC-seq peaks (merging peaks conserved at the Valvatida+Asteroidea strata and Odontophora+Echinoidea strata), gene models (with those included within the conserved syntenic blocks colored in green), insulation scores and computationally called TAD boundaries. Note that the conserved block containing Foxa and Pax1/9 is split in two in the case of sea urchin.

Back to article page