Extended Data Fig. 4: Cohesin and CTCF phylogeny and conservation. | Nature Ecology & Evolution

Extended Data Fig. 4: Cohesin and CTCF phylogeny and conservation.

From: Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes

Extended Data Fig. 4

a, ML phylogenetic tree of cohesin subunit SA1-3 proteins. Sponge SA proteins were used as outgroups. b, ML phylogenetic tree of CTCF, including the tetrapod-specific paralog CTCFL (also known as BORIS), the outgroup (OG) branch includes the insect proteins CROOKED LEGS, a zinc finger containing family of transcription factors. c, Alignment of CTCF proteins from different bilaterians, showing the region containing its putatively ancestral 11 zinc finger domains, where ambulacrarian species have lost one or two domains. Silhouettes from PhyloPic under a Creative Commons license: sponge (Staurocalyptus solidus), whale shark and Onychophora (CC0 1.0) and sea star (CC BY 3.0).

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