Extended Data Fig. 7: Global evolutionary scenario of HORBEC.
From: Evolution and diversity of oxidoreductases involved in redox balance and energy conservation
Time goes from the left to the right. Each line corresponds to inheritance links, notably inferred from the phylogenetic analysis presented in Fig. 2 and Extended Data Fig. 1. The color of lines and components corresponds to the modules. When only a subset of components from a module are inherited, these are indicated in rounded rectangles on the line. Fusion between several lines indicates a coevolution of components. The unresolved relative placements are represented by multifurcated branches. The length of branch is not proportional to time. “a” before the name of a system or a subunit means “ancestral”. The circles indicate if the HORBEC emerged likely in the universal (LUCA), bacterial (LBCA), archaeal (LACA) ancestors, or during diversification of Bacteria (BAC) and Archaea (ARC), in Cyanobacteria (C.b.), or in Methanosarcinales (M.s.). Because of their complexity in terms of evolution, HdrABCDE have not been represented. Rnf and Nqr are also not represented because they do not share homologous subunits with HORBEC. The AI family has not been included because of the lack of phylogenetic signal. The multiple copies of subunits and the functional domain modularity have not been represented.
