Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Autoimmunity

Canagliflozin disrupts T cell activation

Nature Reviews Nephrology volume 19, page 478 (2023)Cite this article

Subjects

Autoreactive T cell function is an important therapeutic target in autoimmunity and a study by Nicholas Jones and colleagues now suggests that the sodium–glucose co-transporter 2 (SGLT2) inhibitor canagliflozin (cana) could be used to modulate T cell activation.

CD4+ T cells from patients with systemic lupus erythematosus or rheumatoid arthritis (RA) also produced less cytokines and failed to upregulate activation markers when stimulated in vitro in the presence of cana. The drug had a similar inhibitory effect on synovial fluid mononuclear cells isolated from patients with RA, suggesting that cana could dampen pathogenic T cell function in autoimmunity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Nephrology http://www.nature.com/nrneph

    Monica Wang

Authors
  1. Monica Wang
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Monica Wang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, M. Canagliflozin disrupts T cell activation. Nat Rev Nephrol 19, 478 (2023). https://doi.org/10.1038/s41581-023-00739-4

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41581-023-00739-4

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing