Extended Data Fig. 8: Time course of measured and expected allele frequencies by ciBE4max.
From: A chemically controlled Cas9 switch enables temporal modulation of diverse effectors
Measured and expected allele frequencies over time created by ciBE4max that show a dependent model of base editing for multiply-edited alleles. Black lines and solid circles show measured allele frequencies, gray lines and open circles show expected allele frequencies. Measured data represented as mean editing frequency ± SEM of 3 cell culture replicates. Expected editing frequency represented as mean expected editing frequency ± relative error. Calculations for expected frequency and relative error described in the methods.
