Fig. 5: Ligand-dependent dynamic rearrangement of the pore region of the KCNQ2 channel.
From: A small-molecule activation mechanism that directly opens the KCNQ2 channel
a, Simulation system of RTG docked into the cryo-EM structure of KCNQ2–Ebio1. b,c, Representation of the distance between residues S303 and F305 from the adjacent subunit (b) or channel pore diameter (c) along the three independent repeats of RTG-dependent MD simulations. d, Typical KCNQ2 channel pore conformations of the two states (initial and final) from the RTG-dependent trajectories. e, Simulation system of Ebio1 docked into the cryo-EM structure of KCNQ2–RTG (ref. 24). f,g, Representation of the distance between residues S303 and F305 from the adjacent subunit (f) or channel pore diameter (g) along the three independent repeats of Ebio1-dependent MD simulations. h, Typical KCNQ2 channel pore conformations of the two states (initial and final) from the Ebio1-dependent trajectories.
