Extended Data Fig. 1: Virtual screening and biophysical characterization of small-molecules on KCNQ2 channel.
From: A small-molecule activation mechanism that directly opens the KCNQ2 channel
a, Chemical structures of initial 15 docking compounds, each with a different scaffold. b, Histogram showing the outward current potentiation effects of 15 candidates on the KCNQ2 channel. The effects of 10 μM candidates are checked at +50 mV. The dash line indicates a potentiation level of 1 (that is no effect). c, The effects of 10 μM candidates on the ΔV1/2 of KCNQ2 channel. NA means the results are not available. n = 3, 3, 2, 2, 2, 3, 3, 3, 3, 2, 3, 6, 3, 5 and 5 (b), n = 2, 2, 2, 4, 2, 2, 2, 3, 6, 2, 3 and 2 (c) biological replicates. Data are presented as the means ± s.e.m.
