Extended Data Fig. 10: Additional data from the synergistic cancer treatment study using HS–E. coli-based whole-cell abiotic catalysts.
From: Artificial metalloenzyme assembly in cellular compartments for enhanced catalysis
a, Statistics on the number of tumors in intestine for all the mice upon death or killing in the mouse colorectal cancer model study. n = 6 biological replicates. b, Statistics on the number of tumors in intestine for mice that survived past day 8 in the mouse colorectal cancer model study. n = 1–5 biological replicates, based on the number of mice survived in each group. c, Mean spleen volumes of the mice survived past day 8 in the mouse colorectal cancer model study. n = 1–5 biological replicates, based on the number of mice survived in each group. d, Representative photographs of mouse organs in the 5 treatment groups. Large tumors are marked by white arrows (markings are not exhaustive, detailed statistics are provided in a). These results clearly demonstrated the effectiveness and reduced toxicity brought by the combination therapy, assisted by whole-cell catalysts that activate drugs at the disease site. **, *** indicate t ≤ 0.01, 0.001 in two-tailed Student’s t-test, respectively. All data are presented as mean ± s.d. where relevant.
