Extended Data Fig. 7: Predicted structural models of hybrid PKSs.
From: Plug-and-play engineering of modular polyketide synthases
a. Sequence alignment of the proteins used to construct hybrid PKSs with the position of cut sites 1–5 marked. AntC does not have KS-AT and only the ACP region is aligned. b. Predicted structures of the enzymes by AlphoFold2. KS domain (yellow), KS-LD-AT linker (cyan), AT domain (green), post-AT linker (magenta), ACP (gray). The extended post-AT linker of VemG is shown in white. The structure files are available at Supplementary Data.
