Extended Data Fig. 4: Ribbon representation of binding of the KLHL domain of KLHL23 and RhoGDI to CDC42.
From: KLHL23 and RhoGDI coordinate CDC42 inactivation ensuring membrane homeostasis
a, The binding model for CDC42 interaction with the KLHL domain of KLHL23 (left) or RhoGDI (right). The middle panel is the merged image for binding the Keltch domain and RhoGDI. The C-terminus of CDC42 interacts only with RhoGDI but not with KLHL. b, A close view of the superimposition of interaction sites on CDC42 shared by KLHL23 and RhoGDI. c, Y64 of CDC42 forms two hydrogen bonds with D42 and K52 of RhoGDI1. Notably, Y64 also forms two hydrogen bonds with H424 and S430 of KLHL23 (Extended Data Figs. 6b and 9a, d).
