Extended Data Fig. 1: Quantitative structure-activity relationship (QSAR) analysis of RNA binding data.
From: Designing small molecules targeting a cryptic RNA binding site through base displacement
a, Schematic representation of the “distance from alkyne”. b, Plot of KD values and “distance from alkyne” for the phenyl-F (9-11) and -CH3 (12-14) series. c, Chemical structures of the para-substituted phenyls (4, 5, 8, 11, 14, and 17-20) with their respective Hammett constant (σp) and van der Waals (VdW) volume values listed. d, Plot of KD values and the σp of the chemical group in the para-substituted phenyls. e, Same as in d but using the VdW volume of the same chemical groups. f, Plot of KD values for the heterocyclic derivatives (21-26) and 8 for comparison. g, Same as in f but for the multi-ring derivatives (27-32). In f and g, mean and s.d. from independent experiments (n = 4 except for data from 21 where n = 5) are shown.
