Extended Data Fig. 5: Selectivity examination of LS-170 toward selected epigenetic ‘readers’ and ‘erasers’. | Nature Chemical Biology

Extended Data Fig. 5: Selectivity examination of LS-170 toward selected epigenetic ‘readers’ and ‘erasers’.

From: Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex

Extended Data Fig. 5: Selectivity examination of LS-170 toward selected epigenetic ‘readers’ and ‘erasers’.

a, Chemical structure of pan-bromodomain inhibitor bromosporine (BS) and probe photo-BS. b, In-gel fluorescent signal to show the inhibitory effects of BS and LS-170 against the Kac readers. c, Chemical structure of H3K4me3 and probe photo-H3K4me3. d, In-gel fluorescent signal to show the inhibitory effects of H3K4me3 and LS-170 against SPIN1 and ING2. e, Chemical structure of competitor H3K9cr and H3K9myr, probe photo-H3K4me3 and photo-H3K9myr. f, In-gel fluorescent signal to show the inhibitory effects of LS-170 against Sirt3 and Sirt6.

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