Extended Data Fig. 8: ATAC inhibition by LS-170 does not affect the expression of ribosomal protein-coding genes.
From: Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex
a, b, Venn diagram showing the overlap of up- (a) and down-regulated (b) genes in LS-170-treated and YEATS2-depleted cells (GSE90781). c, GO analysis of the overlapped genes in LS-170-treated and YEATS2-depleted cells. One-sided Fisher’s Exact test; adjustment was made using Benjamini–Hochberg. d. Volcano plots represent differentially expressed genes, with 81 ribosomal protein genes (RPGs) highlighted as green dots. Two-sided Wald test; adjustment was made using Benjamini–Hochberg. e. Heatmap showing log2FC observed for the four transcription factors involved in the regulation of RPGs expression in the RNA-seq.
