Extended Data Fig. 3: Optimization toward better drug-like properties.
From: Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex
a, Chemical structure of LS-131 and LS-147.b, The radar chart showing the physicochemical properties of LS-131 and LS-147 calculated using the ADMETlab program (https://admetmesh.scbdd.com/). c, Chemical structure of compound LS-147 to LS-159. IC50 for each compound toward YEATS2 YEATS was listed. d-q, Competition curves of LS-147 to LS-159 against YEATS domain of YEATS2. n = 2 independently biological replicates.
