Extended Data Fig. 7: Effects of cell depletion on influenza-specific antibodies and their affinities.
From: Modeling human adaptive immune responses with tonsil organoids
a, Rescue of plasmablast and Ab responses to LAIV stimulation by supplementing pDC-depleted cultures with type I IFNs. b, Frequency of CD4+ T cells (of live cells) in intact and CD4-depleted cultures on day 7. CD4+ cells were depleted by positive selection with magnetic particles. c, Biolayer interferometry data indicating Ab affinity for A/California 2009 H1N1 HA full length, head-specific, and stem domains. Colors are matched to patient samples in (b).
