Extended Data Fig. 4: Impact of 3BNC117 on translationally (p24+) active HIV-1-infected CD4+ T cell subsets. | Nature Medicine

Extended Data Fig. 4: Impact of 3BNC117 on translationally (p24+) active HIV-1-infected CD4+ T cell subsets.

From: Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Extended Data Fig. 4

Data are shown as in Fig. 3b-e, where the ART alone and ART + RMD groups (who only received ART during the first 10 days) are combined into one group and compared to the two 3BNC117-treated groups. Median (error bars represent interquartile ranges) fold change in CD3+CD8- T cell subsets expressing Gag p24 among the combined ART (n = 15) and ART + 3BNC117 (n = 18) groups. The CD3+CD8- T cells subsets are central memory T cells (TCM) (a), naïve T cells (TN) (b), effector memory T cells (TEM) (c), terminally differentiated T cells (TTD) (d), and T follicular helper cells (TFH) (e). P values comparing within group was calculated using paired two-tailed Wilcoxon test. ART, antiretroviral therapy; IQR, interquartile ranges; RMD, romidepsin.

Back to article page