Translational research articles from across Nature Portfolio

Tunable hydrogel-based micropillar arrays are fabricated to model the biomechanical cues of size, shape and rigidity characteristic of axons. These next-gen micropillars allow the exquisite examination of the cell biology of oligodendroglia, resolving the myelinogenic potential, myelin extent and kinetics of wrapping in a cell-autonomous manner.

Early clinical data on in vivo CAR-T cell therapy for multiple myeloma reveals key mechanistic insights and could mark the beginning of a new era of fast, streamlined and accessible immunotherapies.

Deep learning can identify cardiac abnormalities from echocardiogram videos, but previous work has predominantly used 2D video clips from a single cross-section of the heart. Research now shows that more complex approaches that integrate information from several echocardiographic views can improve deep learning prediction of cardiac abnormalities.

Widely used, effective methods to prevent adhesions after digit flexor tendon injury are lacking. Here, authors develop a bioresorbable, supramolecular hydrogel as a lubricating barrier to preserve tendon biomechanics and improve functional recovery.

Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in patients with ARF, linking inflammation to tissue damage.

Here, using data from the COPSAC2010 birth cohort, the authors show that early gut bacteria and having older siblings predict restoration of C-section-perturbed microbiome by age 1, linked to lower asthma risk, with findings replicated in an independent Canadian birth cohort (CHILD).

Tunable hydrogel-based micropillar arrays are fabricated to model the biomechanical cues of size, shape and rigidity characteristic of axons. These next-gen micropillars allow the exquisite examination of the cell biology of oligodendroglia, resolving the myelinogenic potential, myelin extent and kinetics of wrapping in a cell-autonomous manner.

Early clinical data on in vivo CAR-T cell therapy for multiple myeloma reveals key mechanistic insights and could mark the beginning of a new era of fast, streamlined and accessible immunotherapies.