Extended Data Fig. 1: Genes associated with uric acid levels at admission.
From: Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria
a, Uric acid measurement time points in children with severe malaria (SM) and community controls (CC). Transporters of uric acid reabsorption. b, Association between 14 variants and uric acid levels during severe malaria infection, adjusted for age, sex, site and disease severity (Lambaréné Organ Dysfunction Score). Red square and error bars represent a significant association with uric acid levels. c, Prevalence of SLC2A9 variant rs12498742 (location chr4: 9942428:A:G) G allele in cohort 2, Africa, and global populations (gnomAD genomes v3.1.2). d, Uric acid levels at admission and 1-month follow-up according to rs12498742 genotype in children who were admitted with severe malaria are shown in the box-whisker plots (box, median and IQR; whiskers, 1.5× IQR from the box edges; plus sign (+), mean). P-values shown in d are derived from the Kruskal–Wallis test. The figure is created with BioRender.com.
