Extended Data Fig. 3: Association between uric acid levels and probability of in-hospital mortality in cohort 2.
From: Elevated uric acid levels, mortality and cognitive impairment in children with severe malaria
a, Loess regression curve showing the probability of death as a function of uric acid levels in patients with severe malaria. Knots were selected at 3.8 mg/dL based on where the trend in the probability of death shifts from negative to positive and at 7 mg/dL to represent the threshold for hyperuricemia. b, Adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the association between uric acid levels and in-hospital mortality using two-sided logistic regression with restricted cubic splines with knots at 3.8 and 7.0 mg/dL (based on loess smoothing), adjusted for age, sex and site. Odds ratios represent the risk associated with a 1-unit increase in uric acid within each spline segment.
