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Using implementation science to navigate the complexity of integrating genomics into healthcare

Nature Medicine volume 31, pages 1739–1742 (2025)Cite this article

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Australian Genomics led a country-level, longitudinal project to deliver and evaluate the impact of genomics in routine healthcare.

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Fig. 1: Operational facilitators of genomic translational research and medicine.
Fig. 2: Hybrid effectiveness–implementation study designs applied to the rapid genomic testing in acute care study.
Fig. 3: Operational facilitators for delivery of genomics at scale through a complex adaptive systems.

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Authors and Affiliations

  1. Australian Genomics, Melbourne, Victoria, Australia

    Stephanie Best, Ilias Goranitis, Tiffany Boughtwood, Kathryn N. North & Zornitza Stark

  2. University of Melbourne, Melbourne, Victoria, Australia

    Stephanie Best, Ilias Goranitis, Danya F. Vears, Clara L. Gaff, Kathryn N. North & Zornitza Stark

  3. Australian Institute of Healthcare Innovation, Macquarie University, Sydney, New South Wales, Australia

    Jeffrey Braithwaite

  4. Murdoch Children’s Research Institute, Melbourne, Victoria, Australia

    Danya F. Vears, Clara L. Gaff, Tiffany Boughtwood, Kathryn N. North & Zornitza Stark

  5. Genetic Support Network Victoria, Melbourne, Victoria, Australia

    Monica Ferrie

  6. Melbourne Genomics Health Alliance, Melbourne, Victoria, Australia

    Clara L. Gaff

  7. James Cook University, Townsville, Queensland, Australia

    Andrew J. Mallett

  8. The University of Queensland, Brisbane, Queensland, Australia

    Andrew J. Mallett

  9. Townsville University Hospital, Townsville, Queensland, Australia

    Andrew J. Mallett

Authors
  1. Stephanie Best
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  2. Jeffrey Braithwaite
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  10. Zornitza Stark
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Correspondence to Zornitza Stark.

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Best, S., Braithwaite, J., Goranitis, I. et al. Using implementation science to navigate the complexity of integrating genomics into healthcare. Nat Med 31, 1739–1742 (2025). https://doi.org/10.1038/s41591-025-03588-9

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