Extended Data Fig. 2: Paired analysis including prespecified sensitivity analysis.

Two gene panels were used F1CDX (324 genes), Home-based limited panel (CTL) (87 genes). ‡ At patient progression, the MTB reviewed genomic alterations matching with at least one MBRT, based on the first panel as defined per randomization. In the case of failure (no MBRT identification with the first panel), the second panel was disclosed.