Table 3 Associations between weight change and major continental ancestry groups

From: Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery

Major continental ancestry group

Effect on percentage weight change

Standard error

P value

GLP1-RA

   

AFR

0.758

0.327

0.021

AMR

0.874

0.295

0.003

EAS

1.093

0.664

0.100

SAS

0.118

0.759

0.876

BS

AFR

1.688

1.308

0.197

AMR

−0.542

1.428

0.704

  1. Meta-analysis effect sizes, standard errors and P values for the association between weight change and major continental ancestry groups. Coefficients are derived from a multivariable model including percentage weight change as the outcome and ancestry as a categorical variable (with EUR as the reference category), and adjusting for sex, age and weight at baseline and, for GLP1-RA only, medication type. Negative effects indicate higher weight loss. P values are two-sided and were calculated by dividing the coefficient values by their standard errors and observing the probability mass corresponding to equal or more extreme values from both tails of Student’s t distribution.
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