Extended Data Fig. 1: Adolescent Type 1 diabetes Treatment with SGLT2i for hyperglycEMia & hyPerfilTration Trial (ATTEMPT) Schema.

ATTEMPT is a multi-center, double blind, randomized, placebo-controlled trial designed to evaluate the effect of treatment with Dapagliflozin when compared to placebo, in combination with adjustable insulin, on measured GFR and HbA1c in adolescents with T1D over a 22-week evaluation period (16-week treatment period) to test the hypotheses that treatment with dapagliflozin, in combination with adjustable insulin, will reduce mean measured GFR and HbA1c when compared with placebo.