Fig. 4: Immune recovery after briquilimab-containing conditioning and allo-HSCT. | Nature Medicine

Fig. 4: Immune recovery after briquilimab-containing conditioning and allo-HSCT.

From: Irradiation- and busulfan-free stem cell transplantation in Fanconi anemia using an anti-CD117 antibody: a phase 1b trial

Fig. 4

a, Efficient immune recovery of CD3+ T cells, CD19+ B cells and CD16+CD56+ NK cells post allo-HSCT, comparable to other T cell-depleted HSCT approaches. Data are presented as mean ± s.e.m. Each data point represents the average of measurements from three patients. b, Peripheral blood chromosomal breakage studies using the clastogenic agent DEB showing FA-related chromosome breakage in lymphocytes from all patients at screening. Chromosomal breakage was normalized in lymphocytes in each of the patients post-HSCT, with no notable breakage, resembling control values from unrelated healthy donors. Data are presented as mean values, with each point representing the average from 50 cells.

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