Extended Data Fig. 6: Body mass index, adipokine ratios, and ratio aging trajectories by sex.
From: Disruption of the cerebrospinal fluid–plasma protein balance in cognitive impairment and aging
a, Box plot of body mass index (BMI) by sex in the healthy control participants with BMI information available from the Knight (n = 176) and Stanford (n = 57) cohorts. The center line represents the median, box limits represent upper and lower quartiles, and whiskers represent the largest or smallest value not exceeding 1.5x the interquartile range from the box limits. BMI did not significantly differ by sex (p = 0.99, two-sided t-test). b, Scatterplot of BMI (x-axis) and log-transformed CSF to plasma leptin ratio (y-axis). The estimated regression line depicting the association between BMI and log-transformed leptin ratio is plotted, with 95% confidence intervals. The p-value refers to the significance of the BMI coefficient from linear regression of the log-transformed leptin ratio by BMI with age and sex as covariates, and is two-sided. Cohort-level results were aggregated with fixed-effects meta-analysis. c, Scatterplot of BMI (x-axis) and CSF to plasma adiponectin ratio (y-axis). The estimated regression line depicting the association between BMI and adiponectin ratio is plotted, with 95% confidence intervals. The p-value refers to the significance of the BMI coefficient from linear regression of the adiponectin ratio by BMI with age and sex as covariates, and is two-sided. Cohort-level results were aggregated with fixed-effects meta-analysis. d, Scatterplot of estimated meta-analysis age coefficient β for each protein, calculated separately in males (x-axis) and females (y-axis). The correlation between aging coefficients in each sex is indicated (Pearson’s r = 0.91). The estimated regression line with 95% confidence intervals is plotted. e, Scatterplot of signed log10 p-values for the age coefficient in males (x-axis) and females (y-axis). The correlation between signed log10 p-values in each sex is indicated (Pearson’s r = 0.71). The estimated regression line with 95% confidence intervals is plotted. f, g) Scatterplot of age (x-axis) and KNG1 (f) and F10 (g) CSF to plasma ratios (y-axis). Colors indicate sex. The estimated regression line depicting the association between age and protein ratio is plotted for each sex, with 95% confidence intervals.
