Extended Data Fig. 7: Individual plasma proteomic relationships.
From: Characterizing the physiology of circulatory arrest in humans
Arterial (a) and cerebral arterial–venous gradient (b) differences in the plasma proteome were assessed between healthy controls and critically ill patients prior to WLST. Arterial differences in the plasma proteome from prior to WLST to SBP < 60 mmHg was assessed in critically ill patients (c). Data was analyzed on the NULISAseq™ CNS Disease Panel 120 on the ARGO™ HT platform. Data for comparisons between healthy controls and pre-WLST data (a, b) were compared using either two-sided unpaired t-tests or two-sided Mann Whitney U tests depending on whether data was normally distributed and their tests were not corrected for multiple comparisons as this was exploratory and transparent data presentation. Data for comparisons between pre-WLST data and post-WLST data (c) were compared using either two-sided paired t-tests or two-sided Wilcoxon Signed Rank tests depending on whether data was normally distributed and their tests were not corrected for multiple comparisons as this was an exploratory and transparency data collection. Abbreviations: NPQ, NULISA protein quantification; SBP, systolic blood pressure; WLST, withdrawal of life-sustaining treatment.
