Extended Data Fig. 5: Associations of Mediterranean diet index score with dementia risk and cognitive function by genetic factors in Nurses’ Health Study. | Nature Medicine

Extended Data Fig. 5: Associations of Mediterranean diet index score with dementia risk and cognitive function by genetic factors in Nurses’ Health Study.

From: Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function

Extended Data Fig. 5: Associations of Mediterranean diet index score with dementia risk and cognitive function by genetic factors in Nurses’ Health Study.The alternative text for this image may have been generated using AI.

(a) Associations between Mediterranean diet (MedDiet) index score and cognitive function scores by APOE4 genotype from generalized linear models. (b) Associations between MedDiet index score and dementia risk by tertiles of ADRD PRSs from Cox proportional hazards models. (c) Associations between MedDiet index score and cognitive function scores by tertiles of ADRD PRSs from generalized linear models. Stratified β coefficients (for cognitive function) and hazard ratios (HRs; for dementia risk), along with 95% confidence intervals (CIs) per one-unit increase in the MedDiet index score, are shown by APOE4 genotype or PRS categories. The analyses were conducted among NHS participants with genetic, dietary, and cognitive outcome data (n = 16,497 for dementia analyses and n = 3,770 for cognitive function analyses).

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