Extended Data Fig. 9: Harrell’s C index for predicting dementia risk from models with different predictors in Nurses’ Health Study.

APOE4 genotype was not included as a predictor in the subgroup analysis within APOE4 carrier and noncarrier subgroups. The full NHS dataset (n = 4,215) was randomly split into training (60%) and test (40%) sets. All prediction models were fitted in the training set and were evaluated in the test set. All results shown are from the test set.