Table 1 Characteristics of SURMOUNT-1 participants at baseline
From: Tirzepatide leads to weight reduction in people with obesity due to MC4R deficiency
Characteristic | MC4R mutation carriers (n = 32)a | Noncarriers (n = 2,259)a | P valueb |
|---|---|---|---|
Age, years | 41.06 (13.12) | 45.23 (12.36) | 0.043 |
Female sex, no. (%) | 20 (62%) | 154 (68%) | |
Duration of obesity, years | 16.38 (9.17) | 14.40 (10.88) | 0.11 |
BMI, kg m−2 | 40.04 (6.21) | 38.04 (6.88) | 0.036 |
BMI category, no. (%) | 0.084 | ||
<35 | 7 (22%) | 907 (40%) | |
≥35 to <40 | 10 (31%) | 631 (28%) | |
≥40 | 15 (47%) | 721 (32%) | |
Waist circumference, cm | 120.44 (15.95) | 114.02 (15.18) | 0.012 |
Glycated hemoglobin, % | 5.57 (0.48) | 5.56 (0.37) | 0.71 |
Fasting glucose, mg dl−1 | 95.20 (10.54) | 95.50 (10.10) | 0.72 |
Fasting insulin, mIU l−1 | 15.40 (9.08) | 14.02 (10.44) | 0.31 |
Blood pressure, mm Hg | |||
Systolic | 121.31 (13.35) | 123.59 (12.62) | 0.43 |
Diastolic | 79.5 (8.10) | 79.56 (8.14) | 0.91 |
Heart rate, beats min−1 | 72.50 (10.13) | 72.13 (9.52) | 0.83 |
Lipid levels, mg dl−1 | |||
Total cholesterol | 183.56 (36.94) | 191.91 (38.94) | 0.22 |
HDL cholesterol | 45.87 (11.99) | 48.96 (13.04) | 0.23 |
LDL cholesterol | 108.71 (33.35) | 114.52 (32.81) | 0.31 |
Triglycerides | 148.14 (73.44) | 145.80 (107.45) | 0.52 |
